Gout: The ‘disease of kings’ can strike anyone, especially the overweight
For centuries, gout was thought of as a disease of the wealthy or the gluttonous. It’s probably because many foods that cause flare-ups were once luxuries.
Today, one to five million Americans, most neither rich nor self-indulgent, suffer the pain of gout. Most are overweight and over 40.
Gout is a type of arthritis in which glasslike shards of uric acid jab into the joints, causing searing pain. The big toe is often affected. Fever and chills may develop during an attack.
Normally, purines are broken down into uric acid. Uric acid dissolves in the blood, is filtered out by the kidneys, and eliminated in the urine. People with gout either produce too much uric acid or have trouble getting rid of it.
What a patient eats can trigger an attack. Liver, beef, pork, lamb, and all seafood have a high purine content. Overindulgence can cause a flare-up.
One study linked lower alcohol consumption to fewer gout attacks. Study authors noted, however, that those who drank alcohol also drank less milk. Low fat dairy products can help prevent an attack because the proteins in milk reduce uric acid levels.
There is no cure for gout, but high doses of NSAIDs such as aspirin and ibuprofen may control the pain. Prednisone can reduce the inflammation in people who can’t tolerate NSAIDs.
Newer drugs such as allopurinol lower uric acid levels, but can’t be taken during an attack. Allopurinol prevents the conversion of purine to uric acid.
Other new drugs are in the pipeline for FDA approval, say doctors at Johns Hopkins. Until then, slimming down, eating right, and drinking plenty of water will help lower uric acid levels and decrease the risk of attacks.




